Introduction And Application of Phosphomycin calcium

Phosphomycin calcium is an organic compound with the appearance of white or nearly white crystalline powder, odorless, slightly soluble in water, insoluble in methanol, acetone, trichloromethane, dichloromethane and other solutions.

Mechanism of action:

Phosphomycin calcium has a broad antimicrobial spectrum, with strong antibacterial activity against many Gram-positive and Gram-negative cocci. Specifically, it can include Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Vibrio vulnificus, Serratia marcescens, Shigella, Klebsiella pneumoniae, Yersinia pestis, Pseudomonas aeruginosa, Enterobacteriaceae, and Aeromonas aeruginosa. Phosphomycin calcium inhibits the early synthesis of bacterial cell wall by competitively binding to the same transferase enzyme, therefore, it can cause the bacterial cell wall synthesis to be blocked and lead to its death, and then achieve the bactericidal effect.

Phosphomycin calcium Functional Features:

1. Wide antimicrobial spectrum: Phosphomycin calcium can effectively eliminate many Gram-positive and Gram-negative bacteria, and at the same time, it also shows excellent activity against multi-drug-resistant strains such as Pseudomonas aeruginosa, Proteus mirabilis, Serratia marcescens, Staphylococcus spp. and Escherichia coli. The results of clinical application show that no resistance or cross-resistance to animal drugs has been observed, which is an obvious advantage for clinical application.

2. Fast sterilization: after the animals take the medicine, Phosphomycin calciumn can be widely distributed in all tissues and body fluids, and its absorption is not affected by food. When the drug time reaches 6 hours, it can completely eradicate E. coli cells, rapid sterilization and good bactericidal effect.

3. Weak toxic side effects: the adverse reactions of phosphomycin calcium are mainly mild gastrointestinal reactions, with a low incidence, which generally do not affect the continued use of the drug.

4. High safety attributes: the elimination half-life of Phosphomycin calcium in muscle and organs is between 48-72 hours, and it can be used for human and carnivorous animals, and its use is not restricted by countries, with high safety attributes.

Clinical Applications:

In clinical use, Phosphomycin calcium is mainly used for infectious diseases caused by pathogenic bacteria sensitive to Fosfomycin. In animal medicine, it can be applied to acute and chronic intestinal diseases caused by gram-negative bacteria such as Staphylococcus spp, Streptococcus spp, Escherichia coli, Salmonella spp and other birds such as chickens and pigs. At the same time, it can also be used for the treatment of cribbage disease, salmonellosis and other diseases.

Usage Dosage:

Phosphomycin calcium can be mixed with drinking water or feed for livestock and poultry. When mixing with drinking water, add 5-10 grams of Phosphomycin calcium per 100 kilograms of water, take it twice a day for 3 days to have obvious therapeutic effect; when mixing with feed, add 10-15 grams of Phosphomycin calcium per 100 kilograms of feed, take it twice a day for 3 days to have obvious therapeutic effect.

Matters need attention:

1. Phosphomycin calcium is often synergistic when co-administered with antibiotics such as beta-lactams and aminoglycosides, and may reduce or delay the development of bacterial resistance.

2. Phosphomycin calcium inhibits adenosine diphosphate (ADP)-mediated platelet agglutination in vitro, but has not been reported to cause hemorrhage in clinical use, and its use may be of timely concern.

3. Phosphomycin calcium is currently used mainly in pigs, chickens and fish, if the use of other animals, you need to communicate with your veterinarian in a timely manner, under the guidance of his or her use of drugs.