Phosfomycin sodium Description And Application.

Phosfomycin sodium is an organic matter,is epoxyide prol phosphate diodium salt. Potenter shall be not less than 700 fosfomycin units per 1mg. The appearance is white crystalline powder, with wet absorption, very soluble in water, dissolved when releasing heat.

Mechanism of action:

Phosfomycin has antibacterial effect against Gram-positive cocci such as Staphylococcus aureus and Staphylococcus epidermidis. It also showed strong antibacterial activity against Gram-negative bacteria such as Escherichia coli, Serratia, Shigella, Yersinia, Pseudomonas aeruginosa, Klebsiella pneumoniae, Enterobacter aer, Vibrio, and Aeromonas. Fosfomycin inhibits early synthesis of bacterial cell wall by competitively binding to the same transferase enzyme, resembling the molecular structure of phosphoenolpyruvate. Consequently, it hinders bacterial cell wall synthesis and leads to bacterial death. By combining with a bacterial cell wall synthesis enzyme, it hinders the first step of bacteria using the relevant substances to synthesize the cell wall, thus acting as bactericidal. The substance exhibits antibacterial effects against Staphylococcus aureus, Streptococcus pneumoniae, Escherichia coli, Neisseria gonorrhoeae, Pseudomonas aeruginosa, Salmonella typhi, and most strains of Pseudomonas aeruginosa as well as Staphylococcus epidermidis, Streptococcus pyogenes, and Enterococcus faecalis. Additionally, it also demonstrates similar effects on some Gram-positive Proteus species and a few Klebsiella and Enterobacter strains. This kind of antibacterial drugs are not used very much in veterinary clinic, which makes this product is more sensitive to some clinical bacteria. In terms of the mechanism of action, fosfomycin drugs are similar to cephalosporins. Now there are two kinds of veterinary clinical sensitive, one is fosfomycin sodium, the other is fosfomycin calcium.

Function characteristics:

1. Broad-spectrum antibacterial activity: With high bioavailability and rapid absorption, phosphomycin sodium possesses potent antibacterial properties that remain unaffected by diet. It effectively kills both Gram-positive and Gram-negative bacteria, demonstrating excellent activity against multidrug-resistant strains such as Pseudomonas aeruginosa, Proteus mirabilis, Serratia marcescens, Staphylococcus species, and Escherichia coli. Since its introduction in animals, no resistance or cross-resistance has been observed, highlighting its remarkable clinical efficacy.

2. Rapid sterilization with phosphomycin sodium: Exposure to phosphomycin (12.5ug/ml) for 1 hour results in the killing of 25% of Escherichia coli cells, while complete eradication occurs within 4-6 hours. All Staphylococcus aureus cells are completely eliminated.

3. Low side effects of fosfomycin sodium toxicity

4. Low residue: in blood and organs, fosfomycin reaches high levels, and the elimination half-life in muscles and organs ranges from 48 to 72 hours.; it is safe for human consumption.

5, this product is used in carnivores, not restricted by all countries in the world, is indeed a safe and effective green antibiotics.

Clinical application:

It is mainly used in poultry, pigs, salmonella disease, Klebella disease, head swelling syndrome, staphylococcal and streptococcal disease, umbilical, osteomyelitis, encephalitis and fish, shrimp pasteurella, vibrio, streptococcus and other Gram-negative bacteria. The drug is indicated for the treatment of acute and chronic intestinal diseases caused by Staphylococcus genus, Streptococcus, E. coli, Salmonella, and other gram-negative bacteria in chickens, ducks, and pigs.

Usage and dosage:

For livestock and poultry drinking water: Add 5-10 grams of this product per 100 kilograms of water, twice daily for three consecutive days.

For mixed feed for livestock and poultry: Add 10-15 grams of this product (for pigs, chickens, fish) to every 100 kilograms of feed, twice daily for three consecutive days.

Combination use of fosfomycin sodium: Phosfomycin sodium is used for the treatment of intestinal infection, can be combined with β-lactam and aminoglycoside; for the treatment of suction duct and lung infection, combined with macropropyl ester and β-lactam; for the treatment of Staphylococcus aureus infection, combined with erythromycin and rifampin; for the treatment of severe respiratory infection, sepsis, peritonitis, osteomyelitis and other more drugs. And often need to be used with β-lactam or aminoglycosides.

Matters need attention：

1. This product is mainly used for pigs, chickens and fish; other animals have clinical trial reports, and other animals should be used under the guidance of veterinary medicine.

2. Combination phosfomycin, β -lactams, aminoglycosides and macrocyclic esters have synergistic effects, and can reduce or delay the occurrence of bacterial resistance.

3.10-17% may have adverse reactions, mainly mild gastrointestinal reactions, gastric appetite loss, mild diarrhea, which generally do not affect the continuation of medication.